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Pharmacology · single question

A notable side effect of bupropion (Wellbutrin/Zyban) most relevant to dentistry is:

  1. Weight gain and sexual dysfunction
  2. Xerostomia (dry mouth) and lowered seizure threshold
  3. QT prolongation and cardiac arrhythmia
  4. Hypersomnia and constipation
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Correct answer: B. Xerostomia (dry mouth) and lowered seizure threshold

Bupropion inhibits norepinephrine and dopamine reuptake (NDRI). Unlike SSRIs, it causes weight LOSS and no sexual dysfunction. Key dental side effects: (1) Xerostomia — dry mouth increases caries risk; (2) Lowered seizure threshold — clinically important for patients with seizure history. These are the most board-tested bupropion side effects.
  • A. ❌ Bupropion causes weight LOSS (not gain) and has no sexual dysfunction — opposite of SSRIs.
  • B. ✅ Xerostomia + lowered seizure threshold — the two key bupropion side effects relevant to dental practice.
  • C. ❌ QT prolongation is associated with certain antipsychotics (haloperidol) — not bupropion.
  • D. ❌ Bupropion is activating/stimulating — it causes insomnia, NOT hypersomnia.

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