Pharmacology · single question

A 66-year-old male with osteoporosis is taking Denosumab (Prolia). He presents with a chief complaint of pain in tooth #30 when biting. Radiographic examination reveals deep caries on tooth #30 extending to the alveolar crest. Which treatment is most appropriate?

  1. Excavate caries and build up with composite
  2. Coronectomy and root canal therapy followed by a removable denture
  3. Crown lengthening followed by root canal therapy and placement of a crown
  4. Extraction of tooth #30 and tooth addition to a denture
Show answer and explanation

Correct answer: A. Excavate caries and build up with composite

  • A. CORRECT. In patients on antiresorptive medications like Denosumab, the goal is to avoid any surgical procedure that could trigger MRONJ. The most conservative option — excavating the caries and placing a composite build-up — avoids surgery entirely while addressing the immediate pathology. This is the safest approach in this patient.
  • B. Coronectomy still involves surgical osseous intervention, which carries MRONJ risk in patients on Denosumab and should be avoided.
  • C. Crown lengthening is a surgical procedure involving bone removal. In a patient on Denosumab (an antiresorptive/RANKL inhibitor), surgical bone manipulation significantly increases the risk of MRONJ (Medication-Related Osteonecrosis of the Jaw), making this option high-risk.
  • D. Extraction is contraindicated in patients on Denosumab due to the high risk of MRONJ following tooth removal. Even though the caries is extensive, extraction should be avoided whenever possible.

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