Pharmacology · single question
In a patient with liver disease, which antibiotic choice is most appropriate for a dental infection?
Show answer and explanation
Correct answer: A. Penicillin V (pen VK)
- A. Correct. Penicillin V is primarily renally excreted with minimal hepatic metabolism, making it the safest antibiotic choice in patients with liver disease. No dose adjustment is typically needed.
- B. Clindamycin is extensively hepatically metabolized and should be used cautiously or dose-reduced in liver disease.
- C. Metronidazole undergoes significant hepatic metabolism; it requires dose reduction in severe hepatic impairment.
- D. Tetracycline is hepatotoxic and contraindicated in liver disease.