Micro & Immunology · single question

A 10-year-old child received local anesthesia and developed diarrhea, nausea, vomiting, and rash immediately after. What is the diagnosis?

  1. Type IV hypersensitivity reaction
  2. Type III hypersensitivity reaction
  3. Type II hypersensitivity reaction
  4. Type I hypersensitivity reaction
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Correct answer: A. Type IV hypersensitivity reaction

  • A. Correct. Immediate-onset systemic symptoms (GI upset + rash) after allergen exposure indicate IgE-mediated Type I hypersensitivity (anaphylactic/allergic reaction).
  • B. Incorrect. Type II (cytotoxic) involves antibody-mediated cell destruction (hemolytic anemia) — not this acute multi-system presentation.
  • C. Incorrect. Type III (immune complex) causes serum sickness typically 7–14 days after exposure, not immediate.
  • D. Incorrect. Type IV (delayed/cell-mediated) takes 48–72 hours, not immediate onset.

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