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Micro & Immunology · single question

All of the following are TRUE about platelets EXCEPT:

  1. Platelets are derived from megakaryocytes (not Factor VIII)
  2. Platelet half-life is approximately 7–10 days
  3. Platelet counts are generally similar between males and females (females tend to have slightly higher counts)
  4. Platelets are produced in response to Factor VIII
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Correct answer: D. Platelets are produced in response to Factor VIII

Platelets are derived from megakaryocytes in the bone marrow, NOT from Factor VIII. Factor VIII is a coagulation factor involved in the intrinsic clotting pathway — it has nothing to do with platelet production. Thrombopoietin (TPO) stimulates megakaryocyte differentiation. Platelet lifespan is 7–10 days (correct). Regarding sex differences: females actually tend to have slightly higher platelet counts, so 'more platelets in men than women' is the FALSE statement.

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