Pharmacology · single question
Which of the following opioids is classified as SEMI-SYNTHETIC?
Show answer and explanation
Correct answer: B. Hydrocodone
Hydrocodone is semi-synthetic — derived from codeine (natural) but chemically modified. Semi-synthetics: hydrocodone, oxycodone, oxymorphone, hydromorphone, buprenorphine. Natural: morphine, codeine. Fully synthetic: fentanyl, tramadol, meperidine, methadone.
- A. Fentanyl is FULLY SYNTHETIC — created entirely in laboratory, ~100x more potent than morphine.
- B. CORRECT. Hydrocodone = semi-synthetic. Derived from codeine via chemical modification.
- C. Codeine is also NATURAL — methylated morphine, directly from opium.
- D. Morphine is a NATURAL opioid — derived directly from opium poppy without modification.