Pharmacology · single question

What is the most appropriate reversal agent for a patient who presents confused and uncoordinated after taking oral diazepam (Valium) for dental anxiety?

  1. Flumazenil (Romazicon)
  2. Acetylcysteine (Acetadote)
  3. Naloxone (Narcan)
  4. Atropine (AtroPen)
Show answer and explanation

Correct answer: A. Flumazenil (Romazicon)

  • A. Correct. Flumazenil is a competitive benzodiazepine antagonist that reverses the sedative, amnestic, and respiratory depressant effects of benzodiazepines (including diazepam). It is the specific reversal agent for benzodiazepine overdose.
  • B. Acetylcysteine reverses acetaminophen (Tylenol) hepatotoxicity — not benzodiazepine overdose.
  • C. Naloxone (Narcan) is an opioid (mu receptor) antagonist — it reverses opioid toxicity (e.g., morphine, fentanyl), not benzodiazepine effects.
  • D. Atropine is a muscarinic antagonist used for bradycardia and organophosphate poisoning — not benzodiazepine reversal.

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