Start practicing

Pharmacology · single question

Mechanism of action of statins?

  1. Activate PPAR-alpha receptors
  2. Block intestinal cholesterol absorption
  3. Inhibit HMG-CoA reductase, reducing hepatic cholesterol synthesis
  4. Directly increase LDL receptor expression
Show answer and explanation

Correct answer: C. Inhibit HMG-CoA reductase, reducing hepatic cholesterol synthesis

Statins inhibit HMG-CoA REDUCTASE — rate-limiting enzyme in mevalonate pathway. Reduces hepatic cholesterol, upregulates LDL receptors, lowers serum LDL. Side effects: myopathy/rhabdomyolysis, hepatotoxicity.

Practice Pharmacology questions Pharmacology study notes

More Pharmacology practice questions