Pathology · single question

Which of the following is TRUE about HPV (Human Papillomavirus)?

  1. It is the most common cause of nasopharyngeal cancer
  2. It is the least common sexually transmitted infection
  3. HPV is the most common cause of oropharyngeal cancer in the USA
  4. HPV has no vaccine available
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Correct answer: C. HPV is the most common cause of oropharyngeal cancer in the USA

✓ C) HPV is the most common cause of oropharyngeal cancer in the USA is correct.
HPV (particularly HPV-16) has surpassed tobacco as the leading cause of oropharyngeal squamous cell carcinoma in the United States. HPV-positive oropharyngeal cancers have a BETTER prognosis than HPV-negative cancers. HPV is actually the MOST common sexually transmitted infection (not least common). Nasopharyngeal carcinoma is associated with Epstein-Barr virus (EBV), not HPV. The HPV vaccine (Gardasil 9) is available and prevents HPV-16/18 infection.

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