Which of the following is the most serious potential side effect associated with Lisinopril use?

Lisinopril is an ACE inhibitor. While dry cough and angioedema are very well known, among the listed options HYPERKALEMIA is the most serious. ACE inhibitors decrease aldosterone → decreased potassium excretion → hyperkalemia, which can cause fatal cardiac arrhythmias. Dizziness is common but not life-threatening. Skin rash is manageable. Muscle cramps are minor. Hyperkalemia is the most dangerous among these choices. B is correct.