Pharmacology · single question

A female patient taking estradiol (oral contraceptive) is getting an extraction. All of the following are TRUE about giving antibiotics EXCEPT:

  1. Antibiotic can cause gastrointestinal disturbances
  2. Antibiotic can hinder analgesics
  3. Can result in allergic reaction
  4. Antibiotic can hinder contraception effectiveness
Show answer and explanation

Correct answer: C. Can result in allergic reaction

  • A. Incorrect — this IS true. Antibiotics can reduce enterohepatic circulation of estrogens, potentially reducing OCP effectiveness.
  • B. Incorrect — this IS true. GI disturbances (nausea, diarrhea) are common antibiotic side effects.
  • C. Correct — this is the EXCEPTION. Antibiotics do NOT significantly hinder/interact with standard analgesics. There is no clinically significant pharmacokinetic interaction between dental antibiotics and analgesics.
  • D. Incorrect — this IS true. Allergic reactions (rash to anaphylaxis) are a real risk of antibiotic use.

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