Pharmacology · single question

Which of the following is a well-known side effect of bupropion (Wellbutrin/Zyban)?

  1. Depression
  2. Xerostomia (dry mouth)
  3. Hypersalivation
  4. Gingival hyperplasia
Show answer and explanation

Correct answer: B. Xerostomia (dry mouth)

Bupropion (an atypical antidepressant and smoking cessation aid) commonly causes xerostomia (dry mouth) as a side effect due to its norepinephrine-dopamine reuptake inhibitory activity and mild anticholinergic effects. Xerostomia is clinically significant in dentistry as it increases caries risk, causes mucosal discomfort, and affects denture retention. Bupropion does not cause hypersalivation or gingival hyperplasia. Depression is the condition it treats, not a side effect.

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