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Pharmacology · single question

Which of the following does NOT help with osteogenic potential?

  1. IL-1 (Interleukin-1)
  2. Tumor Growth Factor alpha (TGF-α)
  3. BMP (Bone Morphogenetic Protein)
  4. PDGF (Platelet-Derived Growth Factor)
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Correct answer: A. IL-1 (Interleukin-1)

  • A. Correct. IL-1 is primarily a pro-inflammatory cytokine associated with bone resorption (osteoclast activation), not osteogenic (bone-forming) potential.
  • B. TGF-α/β family members support osteoblast proliferation and matrix formation, contributing to osteogenic potential.
  • C. BMPs are well-established osteoinductive growth factors that promote new bone formation.
  • D. PDGF supports cellular proliferation and contributes to bone/wound healing, including osteogenic processes.

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