Which of the following is a characteristic feature of Reed-Sternberg cells in Hodgkin's lymphoma?

Reed-Sternberg (RS) cells are the PATHOGNOMONIC cells of Hodgkin's lymphoma. They are characterized by: LARGE cells with BILOBED or MULTILOBED nuclei with prominent 'owl-eye' nucleoli. They derive from B lymphocytes (A is partially correct but 'bilobed/multilobed nucleus' is the CHARACTERISTIC FEATURE). They are NOT found in non-Hodgkin's lymphoma (D wrong). Their sensitivity to chemo (C) is not their defining histological feature. B (multilobed nucleus) is the defining morphological characteristic. B is correct.