Which odontogenic cyst requires the most aggressive surgical treatment due to its high recurrence rate?

The glandular odontogenic cyst (GOC) is a rare but clinically aggressive odontogenic cyst with a high recurrence rate. It is characterized by a non-keratinized lining with mucous (goblet) cells, duct-like structures, and clear cells. Due to its aggressive behavior, high recurrence rate (up to 55% with conservative treatment), and potential for large size, the recommended treatment is aggressive — ranging from marginal resection to segmental jaw resection with long-term follow-up. Conservative enucleation has high recurrence rates. Dentigerous and radicular cysts rarely recur with simple enucleation. Keratocystic odontogenic tumors (KCOT) also have high recurrence rates but are less aggressive than GOC.