Physiology & Biochemistry · patient case question
Which metabolic component is involved in gout?
Patient case: Patient with gout
Scenario: A patient with GOUT.
Show answer and explanation
Correct answer: A. Nucleic acids (purine metabolism)
- A. Correct. Gout results from disordered PURINE metabolism. Purines from nucleic acid breakdown are catabolised by xanthine oxidase to URIC ACID; when serum urate is high, monosodium urate crystals precipitate in joints producing acute inflammatory arthritis — classically the first metatarsophalangeal joint (podagra).
- B. Amino acid disorders produce conditions such as phenylketonuria and homocystinuria, not gout.
- C. Fatty acid and lipid disorders produce hyperlipidaemias and atherosclerosis.
- D. Carbohydrate metabolism disorders include diabetes mellitus and the glycogen storage diseases.
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