Pharmacology · single question

Which medication is the most effective single agent for smoking cessation?

  1. Nicotine replacement therapy
  2. Varenicline
  3. Bupropion
  4. Clonidine
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Correct answer: B. Varenicline

  • A. NRT is effective but generally less so than varenicline as monotherapy.
  • B. Correct. Varenicline (a partial nicotinic-receptor agonist) has the highest quit rates among single agents.
  • C. Bupropion roughly doubles quit rates but is less effective than varenicline.
  • D. Clonidine is a second-line agent with more side effects and lower efficacy.

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