Pharmacology · single question
What is the mechanism of action of omeprazole?
Show answer and explanation
Correct answer: A. Irreversible inhibition of the gastric H+/K+ ATPase (proton pump)
- A. Correct. Omeprazole is a prodrug activated in the acidic parietal-cell canaliculus, where it irreversibly binds the proton pump. Dental relevance: chronic PPI use is linked to reduced calcium/B12 absorption and altered bone metabolism.
- B. That describes antacids such as calcium carbonate.
- C. That describes sucralfate.
- D. That describes ranitidine and famotidine.