Medical Emergencies · single question

Which is most detrimental during a sickle cell crisis?

  1. Apoptosis of red blood cells
  2. Increased red blood cell half-life
  3. Clumping/occlusion of blood vessels
  4. Decreased hemoglobin polymerization
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Correct answer: C. Clumping/occlusion of blood vessels

  • A. INCORRECT. Hemolysis occurs, but vaso-occlusion drives the acute crisis.
  • B. INCORRECT. Sickle cells have a shortened, not increased, lifespan.
  • C. CORRECT. Sickled cells clump and occlude vessels, causing painful ischemic vaso-occlusive crises and organ damage.
  • D. INCORRECT. Crises involve increased polymerization of deoxygenated HbS, not decreased.

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