Which is considered the gold-standard diagnostic test for Sjogren syndrome, and which antibodies are characteristically positive?

Labial minor salivary gland biopsy showing focal lymphocytic sialadenitis is the gold-standard confirmatory test; anti-SSA(Ro) and anti-SSB(La) antibodies are characteristic serologic findings, with the Schirmer test documenting reduced tear production.Other options: Schirmer and sialometry support but do not confirm the diagnosis; a CBC is not diagnostic (it appeared as the 'EXCEPT' answer in a related item asking which is NOT a Sjogren test).Key exam takeaway: Sjogren workup: anti-SSA/SSB, Schirmer test, reduced salivary flow; minor salivary gland biopsy is the gold standard. CBC is not a Sjogren-specific test.