Pharmacology · single question
Which is a SIDE EFFECT of Bupropion that is most relevant in dentistry?
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Correct answer: A. Xerostomia
Xerostomia (A) — dry mouth — is the most clinically relevant dental side effect of Bupropion. Bupropion (Wellbutrin/Zyban) is a norepinephrine-dopamine reuptake inhibitor (NDRI). By increasing catecholamine levels, it reduces salivary flow via adrenergic mechanisms.
• Xerostomia increases caries risk, causes oral discomfort, and affects denture retention — all directly relevant in dentistry.
• Depression (B) is actually what Bupropion TREATS, not a side effect.
• Anxiety (C) can occur as a side effect but is less clinically impactful for dentistry than xerostomia.
• Bupropion is also used for smoking cessation (Zyban) — dual purpose drug.
• Xerostomia increases caries risk, causes oral discomfort, and affects denture retention — all directly relevant in dentistry.
• Depression (B) is actually what Bupropion TREATS, not a side effect.
• Anxiety (C) can occur as a side effect but is less clinically impactful for dentistry than xerostomia.
• Bupropion is also used for smoking cessation (Zyban) — dual purpose drug.