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Periodontics · single question

Which interleukin is NOT involved in the pathogenesis of periodontal disease? (EXCEPT)

  1. IL-6 (Interleukin-6)
  2. MMP (Matrix Metalloproteinases)
  3. IL-1β (Interleukin-1 beta)
  4. IL-2 (Interleukin-2)
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Correct answer: D. IL-2 (Interleukin-2)

Key cytokines in periodontal disease pathogenesis: IL-1β (major pro-inflammatory cytokine — activates osteoclasts, stimulates bone resorption), TNF-α, IL-6, IL-8, PGE₂, and MMPs (matrix metalloproteinases — degrade collagen and periodontal ligament). IL-2 is primarily a T-cell growth factor involved in cell-mediated immunity — it plays a minor/indirect role in periodontal pathogenesis compared to IL-1β, IL-6, and MMPs.
  • A. Incorrect (IL-1β IS involved). IL-1β is the PRIMARY cytokine in periodontal disease — it stimulates osteoclastogenesis and bone resorption.
  • B. CORRECT. IL-2 is primarily a T-cell proliferation factor (adaptive immunity) — it is NOT a primary cytokine in periodontal pathogenesis. IL-1β, TNF-α, IL-6, and MMPs are the key players.
  • C. Incorrect (MMPs ARE involved). Matrix metalloproteinases (collagenases) destroy the collagen matrix and PDL, driving tissue destruction in periodontitis.
  • D. Incorrect (IL-6 IS involved). IL-6 promotes osteoclast differentiation and contributes to periodontal bone loss.

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