Micro & Immunology · single question

Which immunoglobulin is associated with this type of hypersensitivity?

  1. IgG
  2. IgM
  3. IgE
  4. IgA
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Correct answer: C. IgE

IgE is the immunoglobulin responsible for Type I (immediate) hypersensitivity. IgE binds to FcεRI receptors on mast cells and basophils. Cross-linking by antigen triggers degranulation and histamine release. IgG is involved in Type II and IV. IgM activates complement in Type II. IgA is the secretory mucosal immunoglobulin.

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