Pathology · single question

Which HPV types are responsible for squamous cell carcinoma (SCC) in the tonsils?

  1. HPV 6 and 11
  2. HPV 16 and 18
  3. HPV 31 and 33
  4. HPV 1 and 2
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Correct answer: B. HPV 16 and 18

HIGH-RISK HPV types (oncogenic) = HPV 16 and 18. These are associated with oropharyngeal SCC (especially tonsils and base of tongue), cervical cancer, and other anogenital cancers. HPV 16 is the most common in oropharyngeal SCC (>90% of HPV+ oropharyngeal cancers). LOW-RISK HPV types 6 and 11 cause benign condyloma/warts and recurrent respiratory papillomatosis (NOT cancer). HPV 31/33 are other high-risk types but less common in tonsil SCC. B is correct.

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