Pathology · single question
Which HPV genotype is MOST commonly associated with oropharyngeal squamous cell carcinoma in the USA?
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Correct answer: C. HPV 16
HPV 16 is the most common genotype in oropharyngeal SCC (tonsil, base of tongue). HPV-positive oropharyngeal cancer has better prognosis than HPV-negative disease. HPV 6 and 11 cause condyloma/genital warts; HPV 18 is associated with cervical cancer.