Pharmacology · single question

Which does NOT reduce salivary flow?

  1. Antihistamines
  2. Atropine
  3. Amitriptyline
  4. Cevimeline (Evoxac)
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Correct answer: D. Cevimeline (Evoxac)

CEVIMELINE = MUSCARINIC M3 RECEPTOR AGONIST → INCREASES salivary flow. Used to TREAT xerostomia in Sjogren's. All others DECREASE salivary flow: amitriptyline (TCA anticholinergic), atropine (classic anticholinergic), antihistamines (H1 blockers with anticholinergic effects).

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