Pharmacology · single question
What is the mechanism of action of nitroglycerin?
Show answer and explanation
Correct answer: D. Activates guanylyl cyclase via release of nitric oxide
- A. ❌ COX inhibition is the mechanism of NSAIDs like aspirin and ibuprofen.
- B. ❌ Calcium channel blockers (amlodipine, verapamil) are a separate drug class.
- C. ❌ CAMP is increased by beta-agonists and phosphodiesterase inhibitors. Nitroglycerin works through cGMP.
- D. ✅ Correct. Nitroglycerin releases nitric oxide (NO) in smooth muscle, which activates guanylyl cyclase → increases cGMP → smooth muscle relaxation → vasodilation. This reduces cardiac preload and afterload, relieving angina.