Pathology · single question

Which clinical sign helps IDENTIFY mucous membrane pemphigoid?

  1. Nikolsky sign
  2. Wickham's striae
  3. Cobblestone mucosa
  4. Fordyce spots
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Correct answer: A. Nikolsky sign

The Nikolsky sign (applying lateral pressure to normal-appearing skin/mucosa causes it to blister) is positive in pemphigus and MMP — indicates fragile, weakened epithelial-connective tissue junction due to basement membrane antibodies. Wickham's striae = lichen planus. Cobblestone = Crohn's. Fordyce spots = ectopic sebaceous glands. Nikolsky = vesiculobullous disease.

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