Pharmacology · single question
Which class of medication is associated with calcification of the pulp chamber?
Show answer and explanation
Correct answer: C. Statins
- A. Antihistamines cause xerostomia, not pulp calcification.
- B. PPIs affect calcium and magnesium absorption systemically but are not linked to pulp chamber calcification.
- C. Correct per the source. STATINS (HMG-CoA reductase inhibitors) have been associated with pulp canal calcification and narrowing of the pulp chamber. The proposed mechanism involves statin-induced stimulation of odontoblast/osteoblast differentiation and mineralization (statins upregulate BMP-2). Clinically this matters because it complicates access and canal negotiation during endodontic treatment.
- D. Penicillins have no effect on pulpal mineralization.
Note: Reported in dental literature; mechanism relates to statins' effects on mineralization/calcification.