Pathology · single question
Which cell type is responsible for the formation of dentin, and thus is responsible for dentinogenesis imperfecta?
Show answer and explanation
Correct answer: B. Odontoblasts
Odontoblasts are the cells that form dentin throughout life. In dentinogenesis imperfecta, a mutation in the DSPP gene causes odontoblasts to produce defective dentin, resulting in the characteristic opalescent, discolored teeth with obliterated pulp chambers and root canals. Ameloblasts form enamel; cementoblasts form cementum; fibroblasts form connective tissue.
- A. ❌ Fibroblasts form connective tissue and are not responsible for dentin formation.
- B. ✅ CORRECT – Odontoblasts form dentin; defective odontoblastic function leads to dentinogenesis imperfecta.
- C. ❌ Ameloblasts are responsible for enamel formation (amelogenesis imperfecta when defective).
- D. ❌ Cementoblasts form cementum — not involved in dentinogenesis imperfecta.