Pathology · single question

A patient has a white lesion on the floor of the mouth that cannot be wiped off, without ulceration. What is the most likely diagnosis?

  1. Squamous cell carcinoma (SCC)
  2. White sponge nevus
  3. Lichen planus
  4. Oral candidiasis
Show answer and explanation

Correct answer: A. Squamous cell carcinoma (SCC)

  • A. CORRECT. A persistent, non-wipeable white lesion on the high-risk floor of the mouth raises strong concern for SCC and warrants biopsy.
  • B. INCORRECT. White sponge nevus is bilateral, spongy, and present from a young age.
  • C. INCORRECT. Lichen planus usually shows lacy striae, often bilaterally on the buccal mucosa.
  • D. INCORRECT. Candidiasis (pseudomembranous) typically wipes off.

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