Pathology · single question

Which cancer involves multiple punched-out radiolucencies in a young child (age 2u20134)?

  1. Multiple myeloma
  2. Langerhans cell histiocytosis
  3. Leukemia
  4. Soft tissue sarcoma
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Correct answer: B. Langerhans cell histiocytosis

Multiple punched-out radiolucencies in a young child are characteristic of Langerhans cell histiocytosis (peak incidence age 2u20134). Multiple myeloma causes similar radiographs but is a disease of elderly patients (average age 70). Age is the critical differentiator.

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