Pharmacology · single question
What is the reversal agent for benzodiazepine overdose/sedation?
Show answer and explanation
Correct answer: B. Flumazenil
- A. INCORRECT — Naloxone (Narcan) reverses opioid overdose, not benzodiazepine effects.
- B. CORRECT — Flumazenil is a competitive benzodiazepine receptor antagonist that reverses benzodiazepine sedation, anxiolysis, and respiratory depression. It is the specific antidote for benzodiazepine overdose.
- C. INCORRECT — Neostigmine reverses neuromuscular blockade (non-depolarizing NMBAs) by inhibiting acetylcholinesterase.
- D. INCORRECT — Physostigmine is an anticholinesterase used for anticholinergic toxicity reversal, not benzodiazepine reversal.