Pharmacology · single question

What is the primary mechanism of action of nitrous oxide as an anesthetic agent?

  1. NMDA receptor inhibition
  2. GABA receptor activation
  3. Voltage-gated sodium channel blockade
  4. Activation of opioid receptors
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Correct answer: A. NMDA receptor inhibition

Nitrous oxide (N2O) primarily acts as an NMDA (N-methyl-D-aspartate) glutamate RECEPTOR ANTAGONIST. It blocks these excitatory receptors, producing its analgesic and anesthetic effects. It also has some opioid receptor activity (weak — D partially true but NOT primary). Benzodiazepines and barbiturates work via GABA (B wrong). Local anesthetics block sodium channels (C wrong). The primary MOA is NMDA receptor inhibition. A is correct.

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