Pharmacology · single question

Patient allergic to lidocaine. Which alternative local anesthetic can you use?

  1. Tetracaine (also an ester — cross-reactivity possible)
  2. Pilocarpine (not a local anesthetic)
  3. Mepivacaine (amide — different chemical class, generally safe in lidocaine-allergic patients)
  4. Articaine (also an amide, generally safe but similar cross-reactivity considerations)
Show answer and explanation

Correct answer: C. Mepivacaine (amide — different chemical class, generally safe in lidocaine-allergic patients)

  • A. Tetracaine is an ester-type anesthetic; while a different class from lidocaine (an amide), true lidocaine allergy is exceedingly rare and often related to preservatives rather than the amide itself — however, tetracaine is not the answer highlighted here, given the cross-reactivity concerns within the ester class generally.
  • B. Pilocarpine is a cholinergic agonist used for salivary stimulation, not a local anesthetic at all, making it inappropriate here.
  • C. Correct. Mepivacaine is an amide-type local anesthetic from a different specific chemical structure category, generally considered a safe and effective alternative in patients reporting lidocaine allergy/sensitivity.
  • D. Articaine is also an amide, generally well tolerated, but the source material identifies mepivacaine specifically as the answer of choice in this scenario.

Note: For true lidocaine allergy, switching to a different amide (e.g., mepivacaine, bupivacaine) is generally recommended; verify the specific allergy subtype before selecting an alternative.

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