Restorative & Materials · patient case question

What is the most relevant property of a topical fluoride agent for sustained caries prevention?

Patient case: Wear, erosion and a burning mouth

demo: 31-year-old female

chief: Sensitive front teeth that look increasingly thin, and occasional pain that comes and goes.

history: She drinks four cans of soda daily and has a history she is reluctant to discuss regarding eating patterns. She is otherwise well.

meds: None.

findings: Marked erosion of the lingual surfaces of the maxillary teeth with intact buccal surfaces. Smooth, shiny, saucer-shaped cervical lesions on the buccal aspects of several premolars. Parotid regions appear full bilaterally.

  1. Substantivity, the ability to be retained and released over time
  2. Its immediate antibacterial potency
  3. Bioavailability at the moment of application
  4. Its viscosity during application
Show answer and explanation

Correct answer: A. Substantivity, the ability to be retained and released over time

  • A. Correct. Substantivity means the agent binds to oral surfaces and continues releasing fluoride long after application. Calcium fluoride-like deposits act as a reservoir, releasing fluoride when pH drops. This is why fluoride varnish outperforms a rinse that is cleared in minutes, and it is the same property that makes chlorhexidine effective.
  • B. Fluoride does inhibit bacterial enolase at high concentration, but its principal action is on the mineral phase rather than antibacterial.
  • C. Bioavailability at the moment of application matters for uptake, but a high concentration cleared quickly gives little sustained protection.
  • D. Viscosity affects handling and retention time somewhat, but it is not the underlying property being tested.

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