Physiology & Biochemistry · single question

What is the MOST COMMON chromosomal trisomy?

  1. Trisomy 13 (Patau syndrome)
  2. Trisomy 18 (Edwards syndrome)
  3. Trisomy 21 (Down syndrome)
  4. Trisomy 16
  5. XXY (Klinefelter syndrome)
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Correct answer: C. Trisomy 21 (Down syndrome)

✓ C) Trisomy 21 (Down syndrome) is the most common trisomy compatible with life.
Trisomy 21 occurs in ~1/700 live births. Dental features: macroglossia (relative), hypodontia, microdontia, delayed eruption, taurodontism, Class III tendency, high susceptibility to periodontal disease, LOW caries rate. Trisomy 16 is actually most common in spontaneous abortions but almost never seen in live births. Trisomy 18 and 13 have very poor prognosis.

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