Which cells are primarily involved in cherubism's pathophysiology?

Correct answer: B. Osteoclasts

• A. Osteoblasts form bone; the lesion is driven by resorption.
• B. Correct. Cherubism involves excessive osteoclastic, multinucleated giant-cell activity replacing bone with fibrous tissue.
• C. Odontoblasts form dentin, unrelated to this bone lesion.
• D. Fibroblasts populate the stroma but the destructive cells are osteoclasts/giant cells.