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Pharmacology · single question

What is the MOA of ibuprofen?

  1. Selective COX-2 inhibition only
  2. Non-selective, reversible inhibition of COX-1 and COX-2, reducing prostaglandin synthesis
  3. Mu-opioid receptor agonism
  4. Irreversible inhibition of platelet ADP receptors
Show answer and explanation

Correct answer: B. Non-selective, reversible inhibition of COX-1 and COX-2, reducing prostaglandin synthesis

Ibuprofen is a non-selective NSAID that reversibly inhibits both COX-1 and COX-2, decreasing prostaglandin (and thromboxane) synthesis — producing its analgesic, anti-inflammatory, and antipyretic effects, along with GI and renal side effects from COX-1 inhibition.

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