Pharmacology · single question

What is the mechanism of action of naloxone?

  1. ╬╝-opioid receptor antagonist
  2. NMDA receptor antagonist
  3. GABA agonist
  4. Serotonin 5-HT3 antagonist
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Correct answer: A. ╬╝-opioid receptor antagonist

Naloxone is a competitive ╬╝-opioid receptor antagonist used to reverse opioid overdose (respiratory depression, miosis, sedation). Onset is ~1–2 minutes IV. Flumazenil is the benzodiazepine reversal agent (GABA-A antagonist).

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