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Pharmacology · single question

What is the mechanism of action of aspirin?

  1. Acts via coagulation factor VIII
  2. Platelet functional inhibition
  3. Vitamin K antagonism
  4. Fibrinolysis activation
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Correct answer: B. Platelet functional inhibition

  • A. INCORRECT. Aspirin does not act through factor VIII.
  • B. CORRECT. Aspirin irreversibly inhibits COX-1, blocking thromboxane A2 and impairing platelet aggregation for the platelet lifespan.
  • C. INCORRECT. Vitamin K antagonism describes warfarin.
  • D. INCORRECT. Aspirin does not activate fibrinolysis (that describes thrombolytics).

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