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Pharmacology · single question

What is the mechanism of action (MOA) of lisinopril?

  1. Beta-1 adrenergic receptor blockade
  2. Inhibition of angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II
  3. Calcium channel blockade
  4. Loop diuretic action on the ascending loop of Henle
Show answer and explanation

Correct answer: B. Inhibition of angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II

Lisinopril is an ACE inhibitor. Blocking ACE both lowers angiotensin II (a vasoconstrictor) and reduces aldosterone secretion, lowering blood pressure. It also leads to bradykinin accumulation, which explains its classic side effects — dry cough and angioedema.

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