What is the major concern associated with opioid use?

Correct answer: A. Addiction

• A. Correct. Addiction (compulsive use despite harm) is the principal public-health concern driving opioid prescribing restraint.
• B. Physical dependence is expected with chronic use and is distinct from addiction; not the headline concern.
• C. Tolerance is a pharmacologic adaptation, a manageable consequence rather than the major societal concern.
• D. Sedation is a side effect but not the defining major concern.