Pharmacology · single question
What is the MAIN ADDICTIVE component in smokeless tobacco?
Show answer and explanation
Correct answer: C. Nicotine
Nicotine (C) is the primary addictive component in ALL forms of tobacco — including smokeless (chewing tobacco, snuff, dip).
• Nicotine addiction mechanism: binds nicotinic acetylcholine receptors in the brain → releases dopamine in nucleus accumbens → reward/pleasure → dependence and withdrawal symptoms when absent.
• Smokeless tobacco delivers nicotine via oral mucosa absorption — often higher nicotine levels than cigarettes.
• Carbon monoxide (A): only in combustible tobacco (smoke) → causes cardiovascular damage. NOT in smokeless tobacco.
• Tar (B): carcinogens in smoke — NOT present in smokeless tobacco in the same form.
• Smokeless tobacco oral risks: oral cancer (SCC), leukoplakia, nicotinic stomatitis, gingival recession, tooth abrasion, periodontal disease, bad breath.
• Nicotine addiction mechanism: binds nicotinic acetylcholine receptors in the brain → releases dopamine in nucleus accumbens → reward/pleasure → dependence and withdrawal symptoms when absent.
• Smokeless tobacco delivers nicotine via oral mucosa absorption — often higher nicotine levels than cigarettes.
• Carbon monoxide (A): only in combustible tobacco (smoke) → causes cardiovascular damage. NOT in smokeless tobacco.
• Tar (B): carcinogens in smoke — NOT present in smokeless tobacco in the same form.
• Smokeless tobacco oral risks: oral cancer (SCC), leukoplakia, nicotinic stomatitis, gingival recession, tooth abrasion, periodontal disease, bad breath.