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Medical Emergencies · single question

What is the clinical significance of Janeway lesions in endocarditis?

  1. They are painless, red macules or papules on the palms and soles
  2. They are painful ulcers on the mucous membranes
  3. They are caused by emboli in the brain
  4. They are indicative of immune-mediated vasculitis
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Correct answer: A. They are painless, red macules or papules on the palms and soles

Janeway lesions are PAINLESS, hemorrhagic macules/papules on the PALMS AND SOLES — they are caused by septic emboli from infective endocarditis. They are a MAJOR criterion indicator of IE. Don't confuse with OSLER'S NODES which are PAINFUL nodules on finger/toe pads (immune-mediated). Roth spots are retinal hemorrhages in endocarditis. Janeway lesions = painless, palms/soles, embolic. A is correct.

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