What is bupropion (Wellbutrin/Zyban) primarily used for in clinical practice?

Bupropion is an atypical antidepressant (norepinephrine-dopamine reuptake inhibitor, NDRI) with two primary FDA-approved indications: (1) major depressive disorder (MDD) under the brand name Wellbutrin, and (2) smoking cessation (nicotine addiction) under the brand name Zyban. Unlike SSRIs, bupropion does not cause sexual side effects or significant weight gain. Dental relevance: bupropion can cause xerostomia (dry mouth) as a side effect, but it is not USED to treat xerostomia. It is not used for hypertension. While sometimes used off-label for ADHD, it is not a first-line ADHD medication.