What is a recognized side effect of epinephrine administration?

Epinephrine stimulates alpha-1 receptors (vasoconstriction), beta-1 receptors (increased heart rate and contractility), and beta-2 receptors (bronchodilation, and vasodilation in skeletal muscle), with the net systemic effect commonly including increased blood pressure and heart rate — important to consider in patients with uncontrolled hypertension or cardiovascular disease.