Pharmacology · single question
A patient has Factor V Leiden deficiency. What is NOT true about this condition?
Show answer and explanation
Correct answer: D. Use of contraceptives interfere with clot formation
- A. Warfarin IS used for anticoagulation in Factor V Leiden thrombosis events — this IS true.
- B. Factor V Leiden DOES increase DVT risk significantly — this IS true.
- C. Factor V Leiden IS an inherited thrombophilia (autosomal dominant) — resistance to activated protein C leads to excessive clotting.
- D. ⚠️ FLAG — The answer 'use of contraceptives interfere with clot formation' is listed as NOT TRUE about Factor V Leiden. HOWEVER, this is clinically COMPLEX: Factor V Leiden causes a HYPERCOAGULABLE state (too much clotting). Oral contraceptives (estrogen-containing) ALSO increase clotting risk. Therefore, Factor V Leiden + OCP = significantly increased thrombosis risk. The interaction is REAL — OCP does interfere with (worsen) clot formation risk in Factor V Leiden patients. This statement's interpretation as 'not true' is ambiguous in the source. Study groups should review Factor V Leiden carefully.