Pharmacology · single question
What do NSAIDs cause in the fetus (notably late in pregnancy)?
Show answer and explanation
Correct answer: C. Premature closure of the ductus arteriosus
- A. NSAIDs are not specifically associated with direct umbilical cord damage as their primary fetal risk.
- B. NSAIDs are not specifically associated with placental barrier breakdown as their primary fetal risk.
- C. Correct. NSAIDs (via prostaglandin inhibition) can cause premature closure of the fetal ductus arteriosus, particularly when used in the third trimester, a well-established fetal risk.
- D. Neural tube defects are associated with other exposures (e.g., folate deficiency, certain anticonvulsants like valproate), not the classic NSAID-associated fetal risk.