Micro & Immunology · single question

What are the primary functions of secretory IgA (sIgA) in the oral cavity?

  1. Only antibacterial activity
  2. Only antiviral activity
  3. Both antibacterial and antiviral activity (broad mucosal defense)
  4. Complement activation and opsonization
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Correct answer: C. Both antibacterial and antiviral activity (broad mucosal defense)

Secretory IgA (sIgA) provides both antibacterial and antiviral defense. It works primarily by immune exclusion — binding to pathogens and preventing their adherence to mucosal surfaces. For bacteria: inhibits streptococcal adhesion (anti-S. mutans IgA). For viruses: neutralizes viral particles before mucosal entry. sIgA is NOT efficient at complement activation (unlike IgG and IgM) — it works through blocking adherence, not killing.

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